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Saccharomyces boulardii is a healthy, probiotic yeast. Yeast-based probiotics are unique because they’re not harmed by antibiotics, like other probiotics are. Studies also show that Saccharomyces boulardii can help ease digestive upset during antibiotic use. This makes Saccharomyces boulardii the perfect choice for dogs being treated with antibiotics or other medicines that harm gut bacteria.